Inter coach Antonio Conte started new arrival Aleksandar Kolarov but benched fellow summer signings Arturo Vidal and Achraf Hakimi, while Romelu Lukaku partnered Lautaro Martinez up front with Christian Eriksen behind them.
Hoffenheim then grabbed the lead out of the blue with 16 minutes gone when Ermin Bicakcic headed home Dennis Geiger's corner kick to stun Hansi Flick's men.
Fujian kept straight wins until this loss to Shanghai. However, they are set to face more powerful opponents Tianjin and Jiangsu after this round.
There was controversy before the race had even started, as it emerged that Hamilton was under investigation for making two practise starts outside the permitted area of the pit lane on his way to the starting grid.
Midfielder Tony Kroos was confirmed to have torn his left gluteus maximum muscle on Monday and will miss Wednesday's game and the following weekend's trip to face Levante in Valencia.
Also on Tuesday, men's singles seventh seed Matteo Berrettini of Italy cruised to a 6-3, 6-1, 6-3 victory over Canadian Vasek Pospisil.
After a discussion of around 10 minutes between tournament referees and officials, Djokovic was disqualified from the match in accordance with the rules, even though the 17-time Grand Slam winner had not intended to strike the line judge.
Roberto Soldado will probably replace Jorge Molina in the Granada starting 11 on Thursday, while the Darwin Machis will also probably start with Antonio Puertas perhaps dropping to the bench for the Chinese owned club.
Ramos chipped the ball into the middle of the Betis goal to give his side their first win of the season and end Betis' winning start to the campaign.
In the day's other two matches, Kunshan FC was held 1-1 by Sichuan Youbixuan, and Shaanxi Chang'an Athletic beat Jiangxi Liansheng 1-0. Enditem
Reports about Javi Martinez, Mickael Cuisance and Alexander Nuebel possibly leaving after Thiago Alcantara, Ivan Perisic and Philippe Coutinho have already left don't make the situation easier for Hasan Salihamidzic.
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